| 翻訳と辞書 |
| Fuzzy complex ： ウィキペディア英語版 |
Fuzzy complex
Fuzzy complexes are protein complexes, where structural ambiguity or multiplicity exists and is required for biological function.〔Tompa, P. & Fuxreiter, M. (Jan 2008) "Fuzzy complexes: polymorphism and structural disorder in protein-protein interactions". Trends Biochem Sci 33,(1): 2-8. PMID 18054235.〕〔Fuxreiter, M. & Tompa, P. (2011) Fuzziness: Structural Disorder in Protein Complexes Austin, New York.〕 Alteration, truncation or removal of conformationally ambiguous regions impacts the activity of the corresponding complex.〔Pufall, M.A., Lee, G.M., Nelson, M.L., Kang, H.S., Velyvis, A. et al. (Jul 1 2005) "Variable control of Ets-1 DNA binding by multiple phosphates in an unstructured region". Science 309,(5731): 142-5. PMID 15994560.〕〔Bhattacharyya, R.P., Remenyi, A., Good, M.C., Bashor, C.J., Falick, A.M. et al. (Feb 10 2006) "The Ste5 scaffold allosterically modulates signaling output of the yeast mating pathway". Science 311,(5762): 822-6. PMID 16424299.〕〔Liu, Y., Matthews, K.S. & Bondos, S.E. (Jul 24 2009) "Internal regulatory interactions determine DNA binding specificity by a Hox transcription factor". J Mol Biol 390,(4): 760-74. doi: S0022-2836(09)00629-9 ()〕 Fuzzy complexes are generally formed by intrinsically disordered proteins.〔Romero, P., Obradovic, Z., Kissinger, C.R., Villafranca, J.E., Garner, E. et al. 1998) "Thousands of proteins likely to have long disordered regions". Pac. Symp. Biocomputing. 3: 437-448. PMID 9697202.〕〔Wright, P.E. & Dyson, H.J. 1999) "Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm". J Mol Biol 293,(2): 321-31. PMID. 10550212〕 Structural multiplicity usually underlies functional multiplicity of protein complexes 〔Galea, C.A., Nourse, A., Wang, Y., Sivakolundu, S.G., Heller, W.T. et al. (Feb 22 2008) "Role of intrinsic flexibility in signal transduction mediated by the cell cycle regulator, p27 Kip1". J Mol Biol 376,(3): 827-38. PMID 18177895.〕〔Fuxreiter, M., Tompa, P., Simon, I., Uversky, V.N., Hansen, J.C. et al. (Dec 2008) "Malleable machines take shape in eukaryotic transcriptional regulation". Nat Chem Biol 4,(12): 728-37. doi: nchembio.127 () 10.1038/nchembio.127. PMID 19008886.〕〔Wang, Y., Fisher, J.C., Mathew, R., Ou, L., Otieno, S. et al. (April 2011) "Intrinsic disorder mediates the diverse regulatory functions of the Cdk inhibitor p21". Nat. Chem. Biol. 7: 214-221. PMID 21358637.〕 following a fuzzy logic. Distinct binding modes of the nucleosome are also regarded as a special case of fuzziness.〔Belch, Y., Yang, J., Liu, Y., Malkaram, S.A., Liu, R. et al. 2010) "Weakly positioned nucleosomes enhance the transcriptional competency of chromatin". PLoS ONE 5,(9): e12984. doi: 10.1371/journal.pone.0012984. PMID 20886052.〕〔Tsui, K., Dubuis, S., Gebbia, M., Morse, R.H., Barkai, N. et al. (Nov 2011) "Evolution of nucleosome occupancy: conservation of global properties and divergence of gene-specific patterns". Mol Cell Biol 31,(21): 4348-55. doi: MCB.05276-11 () 10.1128/MCB.05276-11. PMID 21896781.〕
== Historical background ==
For almost 50 years molecular biology was based on two dogmas: (i) equating biological function of the protein with a unique three-dimensional structure and (ii) assuming exquisite specificity in protein complexes. Specificity/selectivity is ensured by unambiguous set of interactions formed between the protein and its ligand (another protein, DNA, RNA or small molecule). Many protein complexes however, contain functionally important/critical regions, which remain highly dynamic in the complex or adopt different conformations.〔Fuxreiter, M. (Jan 2012) "Fuzziness: linking regulation to protein dynamics". Mol Biosyst 8,(1): 168-77. doi: 10.1039/c1mb05234a. PMID 21927770.〕 This phenomenon is defined fuzziness. The most pertinent example is the cyclin-dependent kinase inhibitor Sic1, which binds to the SCF subunit of Cdc4 in a phosphorylation dependent manner.〔Nash, P., Tang, X., Orlicky, S., Chen, Q., Gertler, F.B. et al. (Nov 29 2001) "Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication". Nature 414,(6863): 514-21. doi. PMID 11734846.〕 No regular secondary structures are gained upon phosphorylation and the different phosphorylation sites interchange in the complex.〔Mittag, T., Orlicky, S., Choy, W.Y., Tang, X., Lin, H. et al. (Nov 18 2008) "Dynamic equilibrium engagement of a polyvalent ligand with a single-site receptor". Proc Natl Acad Sci U S A 105,(46): 17772-7. doi: 0809222105 ()
10.1073/pnas.0809222105. PMID 19008353.〕
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
■ウィキペディアで「Fuzzy complex」の詳細全文を読む
スポンサード リンク
| 翻訳と辞書 : 翻訳のためのインターネットリソース |
Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.
|
|